Model-informed precision dosing for intravenous vancomycin in adult inpatients — population pharmacokinetics, machine learning and Bayesian individualisation in one secure platform, developed and validated on real-world inpatient data.
Launch GuardDose → How it worksFrom a priori dose estimation to MAP Bayesian individualisation, shared patient database, analytics and batch import — one secure institutional platform.
Two independent models predict individual clearance from routine covariates before any level is drawn; a concordance check flags patients where they disagree.
One or more measured levels individualise clearance and volume using the full dosing history, with a confidence interval on the estimated exposure.
Target AUC₂₄ 400–600 mg·h/L per the 2020 ASHP/IDSA/SIDP guideline. Regimen grid with predicted AUC, peak and trough for every option; loading-dose guidance.
Cases saved centrally with ward, user, outcome and MAP results. Searchable, filterable, reopen any case, export to CSV.
Target attainment, AUC distribution, cases by ward, month and user, PopPK–ML concordance rate — live from the shared database.
Admin, user and viewer roles; ward assignment; suspend or remove accounts; account lockout; full audit log of sign-ins and data changes.
Import hundreds of patients from Excel or CSV. Column names are matched automatically; each row is validated, calculated (MAP if a trough is supplied) and reported individually.
HTTPS, role-based sign-in, session expiry, audit trail. Patient data is stored in the platform database, not in individual browsers, so the whole team sees the same cases.
Developed and validated on adult inpatients across medical, surgical, critical-care and oncology wards, including a dedicated model for patients with haematological malignancy.
From prescription to individualised dose adjustment
Age, sex, weight, height, SCr and regimen. CrCL auto-calculated by Cockcroft–Gault; choose the general or HM population.
Both models predict clearance and AUC₂₄; concordance is checked; the best regimen for the target AUC is suggested. Save to the database.
Trough, peak + trough or any timed samples — at steady state or with the full dose history. Exact sampling time required.
Individual CL, V and AUC₂₄ with 90% CI and uncertainty reduction. New regimen recommended; residuals flagged if inconsistent.
GuardDose is the applied output of a doctoral research programme in pharmacometrics and model-informed precision dosing.
PharmD, MSc, BCPS · Developer and principal author · Senior clinical pharmacist and PhD candidate in pharmacology
Main PhD supervisor · Professor of Pharmacology
Principal investigator and co-advisor · Clinical pharmacy
Doctoral research advisor
Doctoral research advisor · Pharmacometrics and clinical pharmacokinetics